19/08/2014
Queen's Develops Gel In Fight Against Hospital Superbugs
Queen's University scientists have developed a new antibacterial gel that is being lauded as a "breakthrough" in the fight against hospital superbugs.
The team from the School of Pharmacy at Queen’s developed the gel, which acts to kill Pseudomonas aeruginosa, staphylococci and E.coli using natural proteins.
Dr Garry Laverty, from the School of Pharmacy at Queen’s University, and lead researcher, said: "When bacteria attach to surfaces, including medical implants such as hip replacements and catheters, they produce a jelly-like substance called the biofilm. This protective layer is almost impossible for current antibiotics to penetrate through.
"Therefore bacteria deep within this protective layer are resistant as they remain unexposed to the therapy. They grow and thrive on surfaces to cause infections that are very difficult to treat. The only option is often to remove the medical implant leading to further pain and discomfort for the patient. Our gels would prevent this.
"Our gels are unique as they target and kill the most resistant forms of hospital superbugs. It involves the use of gels composed of the building blocks of natural proteins, called peptides. The same ingredients that form human tissue. These molecules are modified slightly in the laboratory to allow them to form gels that will rapidly kill bacteria. This is further evidence of Queen’s research advancing knowledge and changing lives."
The project was developed as part of an international collaboration between the School of Pharmacy at Queen’s and the School of Chemistry at Brandeis University, Waltham, USA. Findings will be published in the journal Biomacromolecules next month.
(IT/CD)
The team from the School of Pharmacy at Queen’s developed the gel, which acts to kill Pseudomonas aeruginosa, staphylococci and E.coli using natural proteins.
Dr Garry Laverty, from the School of Pharmacy at Queen’s University, and lead researcher, said: "When bacteria attach to surfaces, including medical implants such as hip replacements and catheters, they produce a jelly-like substance called the biofilm. This protective layer is almost impossible for current antibiotics to penetrate through.
"Therefore bacteria deep within this protective layer are resistant as they remain unexposed to the therapy. They grow and thrive on surfaces to cause infections that are very difficult to treat. The only option is often to remove the medical implant leading to further pain and discomfort for the patient. Our gels would prevent this.
"Our gels are unique as they target and kill the most resistant forms of hospital superbugs. It involves the use of gels composed of the building blocks of natural proteins, called peptides. The same ingredients that form human tissue. These molecules are modified slightly in the laboratory to allow them to form gels that will rapidly kill bacteria. This is further evidence of Queen’s research advancing knowledge and changing lives."
The project was developed as part of an international collaboration between the School of Pharmacy at Queen’s and the School of Chemistry at Brandeis University, Waltham, USA. Findings will be published in the journal Biomacromolecules next month.
(IT/CD)
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